Crystagen 20 mg

Crystagen Peptide for Sale: The Khavinson EDP Tripeptide Immune Bioregulator

Crystagen peptide is a synthetic tripeptide bioregulator (Glu-Asp-Pro, EDP by single-letter code) developed within the Khavinson peptide program at the St. Petersburg Institute of Bioregulation and Gerontology. Specifically, Chervyakova and colleagues demonstrated that this tripeptide enhances proliferative activity of blood lymphocytes in adult organisms, activates B-cells, and restores immune cell subpopulations under high exercise stress (1). Furthermore, the peptide also induces proliferation of natural killer (NK) cells and increases expression of the CD3 immature T-cell marker.

For researchers investigating immune senescence, thymic involution, lymphocyte biology, NK cell function, or the full Khavinson organ-specific bioregulator panel, crystagen peptide complements Thymalin (thymus polypeptide extract), Epitalon (pineal gland), Cortagen (cerebral cortex), Pinealon (CNS), and Cardiogen (myocardium) in your laboratory. Pure Peptide Factory stocks research-grade crystagen peptide in 10mg vials with domestic cold-chain shipping and batch-specific HPLC documentation. When researchers buy this compound for laboratory work, the defined EDP sequence requires synthesis verification that matches published Khavinson standards.

Why Researchers Buy Crystagen Peptide from Pure Peptide Factory

Documentation for a Defined Immune Tripeptide

Crystagen peptide is a precisely sequenced synthetic bioregulator with the confirmed structure Glu-Asp-Pro (EDP), molecular formula C14H21N3O8, and molecular weight 359.33 g/mol. As a result, every batch we ship includes a lot-specific HPLC chromatogram and mass spectrometry report confirming the molecular weight target and sequence integrity. The Certificate of Analysis is downloadable before your compound ships. Therefore, you can verify synthesis quality before starting any experimental protocol.

Domestic Cold-Chain for Research Reproducibility

Short tripeptides like this compound have high surface-to-volume ratios and absorb moisture readily. Consequently, we store and ship all vials from domestic cold-storage using phase-change cooling rated for 96-hour protection. Furthermore, most orders reach your lab within 1 to 3 business days, protecting peptide integrity throughout transit.

Matched Vial Configurations Across the Khavinson Panel

Our 10mg vial configuration provides the quantity needed for standard research protocols. Additionally, researchers running comparative bioregulator studies can source Crystagen, Thymalin, Epitalon, Cortagen, Pinealon, and Cardiogen in matched vials from a single supplier under identical handling conditions. This eliminates batch variability from your data.

Synthesis Logs Archived for 24 Months

We document and archive every batch. Therefore, if your compliance office requests chain-of-custody records, we provide them without delaying your research.

What Is Crystagen Peptide?

The EDP Tripeptide Immune Bioregulator from the Khavinson Program

Crystagen peptide is a synthetic tripeptide composed of three amino acids: glutamic acid, aspartic acid, and proline (Glu-Asp-Pro, EDP by single-letter code). Unlike Thymalin, which is a polypeptide extract derived from thymus tissue, Crystagen is a defined synthetic tripeptide with a known and verifiable molecular structure. The research published by Chervyakova and the broader Khavinson group established this peptide’s role in modulating immune cell activity, particularly in the context of aging-related immune decline (2).

Molecular Profile of Crystagen Peptide:

• Sequence: Glu-Asp-Pro (EDP)
• Single-letter sequence: EDP
• Molecular Formula: C14H21N3O8
• Molecular Weight: 359.33 g/mol
• Classification: Synthetic tripeptide bioregulator
• Target tissue: Immune system (lymphocytes, thymus, spleen)
• Developer: Vladimir Khavinson, St. Petersburg Institute of Bioregulation and Gerontology
• Discovery framework: Khavinson bioregulator program (40+ years of research)

How Crystagen Peptide Works: Immune Cell Activation and Restoration

Published research by Chervyakova (2014) documents that Crystagen peptide targets multiple immune cell populations through distinct mechanisms. First, the tripeptide enhances proliferative activity of blood lymphocytes in adult organisms. Second, it activates B-cells, promoting humoral immune function. Third, it induces NK cell proliferation and increases CD3 immature T-cell marker expression. Moreover, the research demonstrated that the peptide restored immune cell subpopulation balance following suppression from high exercise stress.

Furthermore, the peptide was shown to inhibit proliferation of embryonic mesenchymal stem cells while simultaneously enhancing adult lymphocyte proliferation. This tissue-specific and age-contextual response pattern is consistent with the broader Khavinson bioregulator model, where short peptides normalize gene expression in target tissues. Although the direct peptide-DNA interaction mechanism remains debated in Western molecular biology, the functional immune outcomes reproduce consistently within the Khavinson research framework (3).

As a result, researchers studying immunosenescence and the reversibility of age-related immune decline have adopted this tripeptide as a tool to investigate lymphocyte restoration and immune cell subset modulation.

Crystagen Peptide Benefits in Research Applications

T-Cell and Lymphocyte Research

The primary research application for this peptide is the study of T-cell proliferation and differentiation. Specifically, published data documents enhanced CD3 expression, indicating increased immature T-cell output. Furthermore, the peptide stimulates helper T-cell and cytotoxic T-cell activity. Therefore, researchers use crystagen peptide benefits to study adaptive immune activation, thymic output markers, and T-cell subset dynamics.

B-Cell and Humoral Immunity Research

Research demonstrates that the tripeptide activates B-cells, enhancing humoral immune function. Consequently, protocols investigating antibody production, B-cell maturation, and humoral response to antigen challenge incorporate this immune bioregulator. Additionally, the peptide provides a tool to study how B-cell compartments change with age and whether peptide intervention can restore youthful B-cell profiles.

NK Cell Function and Innate Immunity

Chervyakova documented that the peptide induces NK cell proliferation. As a result, researchers studying innate immunity, tumor surveillance, and the NK cell compartment in aging models use Crystagen to examine whether short peptide bioregulators can enhance NK-mediated immune responses.

Immune Recovery Under Physiological Stress

The peptide caused restoration in the cell content of main immune subpopulations following high exercise stress in research models. Therefore, studies examining immune suppression and recovery, whether from physical stress, environmental challenge, or age-related decline, incorporate this tripeptide to measure recovery kinetics and immune subset restoration.

Crystagen vs Thymalin: Defined Synthetic vs Polypeptide Extract

Researchers studying the Khavinson immune bioregulator framework often need to choose between the defined synthetic tripeptide and the thymus-derived extract:

Feature	Crystagen (EDP)	Thymalin
Type	Defined synthetic tripeptide	Polypeptide extract from thymus
Sequence	Glu-Asp-Pro (EDP)	Multi-component complex
Molecular Weight	359.33 g/mol	Mixture
Key immune targets	T-cells, B-cells, NK cells	Broad thymic function
Mechanism precision	Defined molecular identity for exact studies	Multiple active components
Best for studying	Specific lymphocyte subset activation	Whole thymus function

For protocols requiring molecular precision with a fully defined compound, this tripeptide is the appropriate tool. By contrast, Thymalin is preferable when studying the multi-component effects of whole thymus extract. Both compounds are available from our inventory under identical handling conditions.

Crystagen Peptide Dosage in Published Research

The following reference is compiled from published Chervyakova and Khavinson group studies. It serves only as a laboratory research design context. We do not provide human dosing recommendations.

Research Model	Dose	Route	Frequency	Reference
Rodent immune aging model	Bodyweight-adjusted (mcg/kg range)	Subcutaneous or intraperitoneal	Daily	Chervyakova 2014
Lymphocyte proliferation assay	Nanomolar to micromolar	In vitro	Per assay	Cell culture protocols
Khavinson clinical (oral, human)	Per published protocol	Oral	10-day cycles, repeat every 6 months	Bioregulator framework

For researchers seeking precise dosing, the published crystagen peptide dosage literature from the Chervyakova and Khavinson groups provides model-specific ranges. Furthermore, the intermittent cycling model, where peptide intervention occurs in 10-day courses rather than continuously, is central to the bioregulator approach.

How to Reconstitute Crystagen Peptide

Step-by-Step Laboratory Protocol

1. Sanitize the vial stopper with 70% isopropyl alcohol.
2. Inject bacteriostatic water or sterile saline slowly against the vial wall. Do not aim directly at the lyophilized cake.
3. Allow the powder to dissolve without agitation for 1 to 2 minutes. Tripeptides dissolve quickly due to small molecular size.
4. Gently swirl until the solution clears. Do not shake vigorously.
5. Inspect for clarity and label with date and concentration before use.

Concentration Reference for 10mg Vial:

• 10mg vial + 1mL water = 10mg/mL
• 10mg vial + 2mL water = 5mg/mL
• 10mg vial + 5mL water = 2mg/mL
• 10mg vial + 10mL water = 1mg/mL

For cell culture work, prepare serial dilutions from a concentrated stock solution.

Storage Requirements

• Lyophilized powder: 24 months at -20°C, protected from light and moisture.
• Reconstituted solution: 14 days at 2 to 8°C. Do not freeze.
• The small tripeptide structure absorbs moisture readily; keep vials sealed and desiccated during long-term storage.

Crystagen Peptide for Sale: Regulatory and Research Context

Regulatory Status

This peptide is registered as a pharmaceutical product in Russia within the Khavinson bioregulator framework. By contrast, the FDA has not approved it in the United States, and no Western pharmaceutical registration exists. Research-grade crystagen peptide is legally available for laboratory procurement under research-use-only terms. This compound is not for human consumption, veterinary use, or diagnostic application. You must agree to research-use-only terms at checkout.

Independent Validation Status

Most published research on this tripeptide originates from the Chervyakova and Khavinson groups. Independent replication by Western research groups remains limited. Therefore, researchers using the compound should engage with the evidence base critically, while acknowledging the consistent reproducibility within the Khavinson framework.

Important note: Some online product pages describe Crystagen as a tissue repair or soft tissue injury peptide. This is incorrect. The published research consistently identifies this compound as an immune system tripeptide bioregulator targeting lymphocyte function, B-cell activation, and NK cell proliferation. Researchers should verify product descriptions against the actual peer-reviewed literature before designing protocols.

Product Specifications

Available Configuration

Crystagen peptide is available in 10mg vials. Select your quantity from the product options above.

Quality Verification

• Purity: 98% minimum (HPLC verified)
• Identity: Mass spectrometry confirmed against the 359.33 g/mol target with EDP sequence verification
• Endotoxin: Less than 0.1 EU/mL
• Sterility: Verified per USP 71
• Form: Lyophilized powder
• Storage: -20°C long-term, 2 to 8°C short-term after reconstitution

Current Batch: #PPF-CRY-0526
Purity: 98.6%
Download: HPLC Certificate | MS Report

Frequently Asked Questions

What is crystagen peptide used for in research?

Researchers use crystagen peptide to study T-cell and lymphocyte proliferation, B-cell activation and humoral immunity, NK cell function, immune recovery following physiological stress, and the reversal of age-related immune decline (immunosenescence) in preclinical models.

Where can I buy crystagen peptide for research?

Pure Peptide Factory stocks research-grade crystagen peptide in 10mg vials with batch-specific HPLC and mass spectrometry documentation. Domestic cold-chain shipping delivers most orders within 1 to 3 business days.

What is the sequence of crystagen?

Crystagen is a tripeptide with the sequence Glu-Asp-Pro (EDP by single-letter code). Its molecular formula is C14H21N3O8, and its molecular weight is 359.33 g/mol.

What are crystagen peptide benefits in research models?

Published research documents enhanced lymphocyte proliferation, B-cell activation, NK cell proliferation, increased CD3 T-cell marker expression, and restoration of immune cell subpopulations following suppression from physiological stress.

What is the crystagen peptide dosage used in research?

Rodent immune aging models use bodyweight-adjusted doses in the mcg/kg range administered subcutaneously or intraperitoneally daily. Cell culture work uses nanomolar to micromolar concentrations. Refer to the dosage table above for full research context.

Is crystagen FDA approved?

No. Crystagen is registered as a pharmaceutical in Russia but has not received FDA approval. Research-grade crystagen is legally available for laboratory procurement under research-use-only provisions.

How does crystagen differ from Thymalin?

Thymalin is a multi-component polypeptide extract from thymus tissue, while Crystagen is a single defined synthetic tripeptide (Glu-Asp-Pro, EDP). Specifically, the synthetic peptide enables more precise mechanistic studies because its molecular identity is fully defined and verifiable. See the comparison table above for full details.

Does crystagen affect B-cells or only T-cells?

Published research documents that crystagen activates B-cells, promotes NK cell proliferation, and enhances T-cell markers including CD3 expression. Therefore, it modulates multiple lymphocyte populations rather than T-cells exclusively.

Is crystagen a tissue repair peptide?

No. Some online product descriptions incorrectly categorize this compound as a tissue repair peptide. The actual published research consistently identifies it as an immune system tripeptide bioregulator targeting lymphocyte function and immune cell populations. Researchers should verify product claims against the peer-reviewed Chervyakova and Khavinson literature.

How should crystagen peptide be stored?

Lyophilized powder stores at -20°C for up to 24 months, protected from light and moisture. Reconstituted solution stores at 2 to 8°C for up to 14 days. Do not freeze reconstituted solution.

Order Crystagen Peptide for Research

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• Discreet labeling with full tracking

Institutional Accounts

Net-30 terms and purchase order acceptance available for universities and research institutions. Contact us for bulk pricing on 50 vials or more, including matched bulk orders for crystagen peptide alongside Thymalin, Epitalon, Cortagen, Pinealon, and Cardiogen for combined Khavinson bioregulator research.

Add to cart and get research-grade crystagen peptide delivered with the documentation your immunosenescence, lymphocyte biology, or Khavinson bioregulator research requires.