CJC-1295 with DAC 5mg

CJC-1295 with DAC Research Peptide: Extended GHRH Analog for GH Axis Studies

Researchers searching for cjc 1295 with dac need a reliable domestic source that guarantees compound integrity and fast delivery. Pure Peptide Factory stocks this long-acting GHRH analog in multiple vial sizes, ships same-day in cold-chain packaging, and delivers to your lab in 1 to 3 business days. We also provide full batch-specific documentation so your compliance office stays satisfied.

CJC-1295 with DAC is a modified growth hormone-releasing hormone analog that includes a Drug Affinity Complex (DAC) moiety. This modification was developed to significantly extend the peptide’s plasma half-life beyond that of native GHRH or shorter fragments like Sermorelin. Consequently, it has become a key tool for researchers studying sustained GH release, prolonged IGF-1 elevation, and the effects of continuous GHRH receptor activation on body composition and metabolism.

Why Researchers Choose Pure Peptide Factory for CJC-1295 with DAC

Domestic Cold-Chain Shipping You Can Trust

Peptide degradation accelerates rapidly when temperature control fails. For this reason, researchers looking for cjc 1295 with dac for sale need a supplier that prioritizes cold-chain logistics. We store all peptides domestically and ship using phase-change cooling technology. As a result, you receive a compound that performs exactly as specified.

Multi-Vial Configurations for Flexible Dosing

We stock this peptide in 2mg, 5mg, and 10mg vials. Whether you are running a small pilot study or a large-scale metabolic protocol, you can source your entire supply from a single batch. Furthermore, our broad range eliminates the need to split vials or order from multiple vendors.

Lot-Specific Documentation

Every order ships with an HPLC chromatogram, mass spectrometry report, and Certificate of Analysis. Moreover, synthesis records are archived for 24 months. Therefore, if your IRB requests verification, you can download the documentation before the package arrives.

Compare Against Other GHRH Analogs Without Batch Variables

Many protocols run CJC-1295 DAC alongside Sermorelin, Tesamorelin, or CJC-1295 without DAC. Because all these compounds are available from our Sermorelin and Tesamorelin inventory under identical storage conditions, you eliminate supplier variability from your data.

What Is CJC-1295 with DAC?

A GHRH Analog Engineered for Extended Action

CJC-1295 with DAC is a synthetic 30-amino acid peptide analog of growth hormone-releasing hormone. The peptide itself is a tetrasubstituted GHRH (1-29) amide, which already has improved stability over native GHRH. However, the key innovation is the addition of the Drug Affinity Complex (DAC) moiety. This maleimidopropionic acid group covalently binds to circulating albumin after subcutaneous administration. As a result, the peptide adopts a half-life of approximately 6 to 8 days, compared to the 10 to 20 minutes of unmodified Sermorelin (1). This dramatic extension is what distinguishes CJC-1295 DAC from other GH secretagogues.

Molecular Profile:

• Molecular Formula: C152H252N44O42 (peptide portion, before conjugation)
• Molecular Weight: ~3,367 Da (peptide); ~5,500 Da with DAC
• Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2
• CAS: 863288-34-0 (CJC-1295 with DAC)
• Synonyms: CJC-1295 DAC, CJC-1295 (DAC), Long-acting GHRH analog

Mechanism of Action — Sustained GHRH Receptor Activation

This GHRH analog binds selectively to GHRH receptors on pituitary somatotroph cells, just as endogenous GHRH does. This binding stimulates adenylyl cyclase, raises intracellular cyclic AMP, and activates protein kinase A. Subsequently, the pituitary releases growth hormone in a tonic, prolonged pattern. Unlike physiological GHRH pulses, which are brief and sporadic, the long-acting analog induces sustained GH elevation over several days. Furthermore, this continuous signaling drives hepatic IGF-1 production to levels that can remain elevated for up to two weeks (2). This sustained axis activation is the primary reason researchers study this compound for metabolic and body composition outcomes.

CJC-1295 with DAC vs Without DAC — The Critical Difference

The presence or absence of the DAC moiety is not a minor variation. It fundamentally changes the peptide’s pharmacokinetics, dosing schedule, and resulting GH release pattern. Understanding this distinction is essential for proper protocol design.

Head-to-Head Comparison Table

Feature	CJC-1295 with DAC	CJC-1295 without DAC (Mod GRF 1-29)
Structure	GHRH (1-29) analog + DAC moiety	GHRH (1-29) analog, no DAC
Half-Life	~6-8 days	~30 minutes
GH Release Pattern	Sustained, tonic elevation	Brief, pulsatile spike
Dosing Frequency in Protocols	Every 3-7 days	Multiple times daily
IGF-1 Elevation Duration	Up to 14 days	2-6 hours
Albumin Binding	Yes (via DAC)	No
Best for Studying	Continuous GH exposure, chronic metabolic effects, infrequent dosing models	Pulsatile GH dynamics, acute response
“GH bleed” Concern	Present — continuous GH leak from pituitary	Absent

When to Choose the Long-Acting Version

Choose CJC-1295 with DAC when your research hypothesis involves prolonged, continuous GHRH receptor activation. Furthermore, if you need to study sustained IGF-1 elevation over days or weeks without frequent injections, this is the appropriate tool. The convenience of infrequent dosing also makes it ideal for long-term metabolic protocols.

When CJC-1295 without DAC Is the Better Option

CJC-1295 without DAC (often called Mod GRF 1-29) preserves the natural pulsatile pattern of GH secretion. Therefore, for studies examining circadian GH rhythms, sleep-related GH pulses, or the physiological integrity of the GH axis, this shorter-acting analog is preferred. You can order both compounds from our GHRH analog collection for direct comparison.

CJC-1295 DAC Dosage Reference for Research Protocols

The following information is compiled from published research literature and is provided solely for preclinical reference. It is not a recommendation for human use. All protocols must be reviewed and approved by your Institutional Biosafety Committee and IRB.

Research Protocol Typical Ranges

Published animal model studies commonly employ this compound at bodyweight-adjusted doses. Because of its long half-life, administration schedules are sparse. As a general research reference, doses examined in rodent metabolic studies range from 0.1 mg/kg to 1.0 mg/kg administered every 3 to 7 days. Exact dosing depends on the model, endpoint, and desired degree of GH/IGF-1 elevation.

CJC-1295 DAC Dosage Chart for Preclinical Models

Research Model	Typical Dose Range	Frequency	Notes
Rodent metabolic studies	0.1 – 0.5 mg/kg	Every 3-5 days	Used for body composition and glucose metabolism research
GH/IGF-1 axis investigation	0.5 – 1.0 mg/kg	Every 5-7 days	Higher doses to produce supraphysiological IGF-1
Long-term aging models	0.2 – 0.4 mg/kg	Every 7 days	Chronic GH elevation, monitoring required
Combination with Ipamorelin	0.2 mg/kg CJC + 0.2 mg/kg Ipamorelin	Every 3 days	Dual axis stimulation; see Ipamorelin combination section below

Important Research-Only Disclaimer

This dosage reference is derived wholly from published preclinical studies. Pure Peptide Factory does not provide medical advice, dosing instructions, or self-administration guidance. Our peptides are for laboratory research only. Any deviation from approved institutional protocols falls outside our intended use scope.

CJC-1295 DAC and Ipamorelin Combination — Dual Axis Stimulation

Many research groups use CJC-1295 with DAC as the GHRH receptor component of a stacked protocol alongside Ipamorelin, a selective ghrelin receptor agonist. The rationale behind this is that activating both the GHRH receptor and the ghrelin receptor simultaneously produces greater GH release than either compound alone. This “double hit” on the somatotroph cell is well-documented in the literature.

Typical Combination Protocols

In preclinical research, combination protocols often pair a long-acting GHRH analog with a shorter-acting ghrelin mimetic like Ipamorelin. The long-acting component provides the tonic, sustained GHRH signal, while Ipamorelin adds higher-amplitude, pulsatile GH peaks without stimulating cortisol or prolactin. Our Ipamorelin research peptide is available in the same cold-storage facility for clean, batch-matched combination studies.

Side Effects and Safety Profile

Published Safety Data

Because this peptide produces sustained GH and IGF-1 elevation, the safety profile observed in published studies mirrors that of prolonged GH/IGF-1 exposure. Research reports potential effects including:

• Joint stiffness and carpal tunnel-like symptoms due to sodium and water retention induced by GH
• Insulin resistance secondary to GH’s anti-insulin action on adipocytes
• Acromegalic-like growth with very high, prolonged dosing in animal models
• Injection site reactions, typically mild and transient
• Elevated prolactin and cortisol — less common than with older GHRH analogs but still possible at high doses

As with all research peptides, institutional biosafety and IRB oversight are mandatory for in vivo studies. No FDA approval exists for CJC-1295 with DAC for human use. This compound is strictly research-grade.

How to Reconstitute CJC-1295 with DAC

Standard Laboratory Protocol

1. Sanitize the vial stopper with 70% isopropyl alcohol.
2. Inject bacteriostatic water slowly against the vial wall. Do not direct the stream at the lyophilized cake.
3. Allow the cake to dissolve without agitation for 3 to 5 minutes. The peptide is more hydrophobic and may take slightly longer to fully dissolve.
4. Gently swirl until the solution is completely clear. Do not shake, as foaming can denature the peptide.
5. Inspect for particulate matter and discard if not fully transparent.

Concentration Reference

• 2mg vial + 1mL bacteriostatic water = 2mg/mL
• 5mg vial + 2mL bacteriostatic water = 2.5mg/mL
• 10mg vial + 2mL bacteriostatic water = 5mg/mL

Storage Guidelines

• Lyophilized powder: 24 months at -20°C, protected from light.
• Reconstituted solution: 28 days at 2 to 8°C. Do not freeze.
• Because of the DAC moiety, the albumin-bound form is stable in vivo, but the reconstituted peptide should still be handled with care to avoid aggregation.

Product Specifications

Available Vial Configurations

This research peptide is available in 2mg, 5mg, and 10mg vials. Select your required size from the product selector above.

Quality Verification

• Purity: 98% minimum (HPLC verified)
• Identity: Mass spectrometry confirmed
• Endotoxin: Less than 0.1 EU/mL
• Sterility: Verified per USP <71>
• Form: Lyophilized powder (acetate salt)
• Storage: -20°C long-term, 2 to 8°C short-term
• Current Batch: #PPF-CJCDAC-0426 | Purity: 98.5% — Download: HPLC Certificate | MS Report

Frequently Asked Questions

What is CJC-1295 with DAC used for in research?

It is primarily used to study sustained GHRH receptor activation, prolonged GH secretion, and subsequent IGF-1 elevation over days to weeks. Researchers employ it in metabolic, body composition, and aging-related protocols.

What is the difference between CJC-1295 with DAC and without DAC?

The DAC moiety binds to albumin, extending the half-life from about 30 minutes (without DAC) to 6-8 days. This changes the GH release pattern from brief pulsatile spikes to sustained tonic elevation. The choice depends on your research goal: pulsatile vs continuous GHRH signaling.

Where can I buy CJC-1295 with DAC?

Pure Peptide Factory supplies research-grade CJC-1295 DAC domestically. Orders placed before 2 PM EST ship same-day with cold-chain packaging and arrive in 1 to 3 business days. No prescription is needed for laboratory procurement under research-use-only terms.

What is CJC-1295 DAC dosage for research models?

In published rodent studies, doses range from 0.1 to 1.0 mg/kg administered every 3 to 7 days depending on the model and endpoint. Refer to the dosage chart and literature for your specific species and protocol. This information is for preclinical reference only.

Is CJC-1295 with DAC safe?

Published preclinical data shows prolonged GH elevation can cause joint stiffness, insulin resistance, and fluid retention in animal models. As a research compound, it requires institutional biosafety oversight and IRB approval for in vivo use. It is not FDA approved for human consumption.

Can I take CJC-1295 with DAC with Ipamorelin?

Many research protocols combine this long-acting GHRH analog with Ipamorelin to simultaneously activate the GHRH receptor and the ghrelin receptor. This is a common approach for studying dual-axis stimulation of GH release. Both peptides are available from our catalog for research protocols.

How should I store CJC-1295 with DAC?

Store lyophilized powder at -20°C for up to 24 months. After reconstitution, keep the solution at 2-8°C and use within 28 days. Do not freeze the reconstituted peptide.

What is the half-life of CJC-1295 with DAC?

The DAC moiety binds to serum albumin and extends the half-life to approximately 6-8 days in published pharmacokinetic studies. This allows for infrequent dosing schedules in research models.

Does CJC-1295 with DAC cause a “GH bleed”?

Because this compound continuously stimulates the pituitary, it can cause a sustained, low-level GH release that differs from natural pulsatile patterns. This is often referred to as a “GH bleed” and is one of the key pharmacokinetic factors researchers study when comparing with and without DAC.

What is CJC-1295 DAC used for on Reddit?

Online forums often discuss CJC-1295 with DAC for self-administration. Pure Peptide Factory does not condone or support human use. Our product is strictly for laboratory research. We recommend researchers base their protocols on peer-reviewed literature, not community anecdotes.

How does CJC-1295 with DAC compare to Sermorelin?

Sermorelin has a half-life of 10-20 minutes and produces pulsatile GH release. This long-acting analog has a 6-8 day half-life and produces sustained GH elevation. Choose based on your research need: natural pulse dynamics vs prolonged axis activation.

Can I buy CJC-1295 with DAC without a prescription?

Yes, for research use under research-use-only terms. This is laboratory procurement, not a prescription medication.

Order CJC-1295 with DAC for Research

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