DSIP 15 mg

Buy DSIP: Research-Grade Delta Sleep-Inducing Peptide (15mg)

Researchers studying sleep architecture, stress axis modulation, or neuroendocrine regulation require a reliable domestic source for delta sleep-inducing peptide. Pure Peptide Factory supplies research-grade DSIP with full batch documentation and cold-chain shipping. Unlike multi-component neuropeptide preparations like our Cerebrolysin complex, DSIP is a single molecular species, making it a clean tool for precise mechanistic studies. When you buy dsip from our domestic stock, you receive a precisely characterized nonapeptide ready for immediate reconstitution and use in your laboratory protocols.

DSIP (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) is a 9-amino acid peptide originally isolated from rabbit cerebral venous blood during deep sleep. Unlike sedatives that suppress neural activity, this endogenous peptide modulates sleep architecture by promoting slow-wave (delta) sleep while preserving REM and light sleep stages. Furthermore, research has documented its effects on the hypothalamic-pituitary-adrenal (HPA) axis, pain perception, and oxidative metabolism. Consequently, researchers who buy dsip gain access to a multi-functional tool for studying the neurobiology of sleep and stress (1).

Why Researchers Buy DSIP from Pure Peptide Factory

Verified Nonapeptide for Sleep Neurobiology

DSIP is a precisely sequenced 9-amino acid peptide with a defined molecular weight of 848.82 g/mol. Unlike multi-component neuropeptide preparations, it is a single molecular species that can be fully characterized by HPLC and mass spectrometry. Every batch we ship includes lot-specific documentation verifying the exact sequence (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) and purity. Therefore, researchers who buy dsip from our facility can be confident that each study uses a consistent, validated compound.

Domestic Cold-Chain Shipping

Peptide integrity degrades with temperature excursion and moisture exposure. Consequently, we store all DSIP inventory domestically under controlled cold-chain conditions and ship using phase-change cooling rated for 96-hour protection. Most orders arrive within 1 to 3 business days, protecting the peptide from degradation during transit. For this reason, researchers searching for where to buy dsip with guaranteed cold-chain integrity choose Pure Peptide Factory.

Compare Against Other Sleep-Related Peptides

Many protocols compare DSIP with other neuropeptides that influence sleep and circadian rhythms, such as Epitalon (pineal gland bioregulator) and Pinealon (CNS bioregulator). Because we stock all three compounds in the same cold-storage facility, researchers who buy dsip alongside these complementary peptides can eliminate batch variability from their comparison data.

Synthesis Logs Archived for 24 Months

Should your compliance office or IRB request chain-of-custody records, we provide them without delay. This documentation standard ensures your research proceeds without administrative interruptions.

What Is DSIP? (Buy DSIP for Research)

A Nonapeptide Isolated from Deep Sleep Physiology

DSIP (delta sleep-inducing peptide, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) is a 9-amino acid peptide first discovered by Monnier and Schoenenberger in 1973. They isolated it from the cerebral venous blood of rabbits during thalamic-induced slow-wave sleep and demonstrated that injection of the purified peptide into recipient animals increased delta-wave EEG activity without sedation (2). Unlike pharmacological sedatives, DSIP does not suppress neuronal activity globally. Instead, it appears to modulate endogenous sleep-regulatory circuits in the hypothalamus and brainstem, promoting the natural transition into slow-wave sleep.

Structurally, it is one of the smallest bioactive peptides known, with a molecular formula of C35H48N10O15 and a molecular weight of 848.82 g/mol. Its small size and hydrophilic character contribute to its rapid distribution and short plasma half-life of approximately 15 minutes. Despite this short half-life, the physiological effects on sleep architecture and stress hormone regulation can persist for hours, suggesting downstream signaling cascades or active metabolites (3).

Key Properties

• Sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
• Molecular Formula: C35H48N10O15
• Molecular Weight: 848.82 g/mol
• CAS Number: 62568-57-4
• Classification: Endogenous sleep-regulating nonapeptide
• Synonyms: DSIP, Delta Sleep-Inducing Peptide, Sleep Peptide
• Half-life: ~15 minutes in plasma

Buy DSIP: Research Benefits and Applications

Sleep Architecture and Delta-Wave Promotion

The most extensively documented dsip peptide benefits relate to sleep architecture. In preclinical models, DSIP administration increases the proportion of slow-wave (delta) sleep without suppressing REM or light sleep stages. Specifically, EEG studies in rodents and rabbits demonstrate increased delta power in the 0.5-4 Hz range following DSIP injection. This distinguishes it from benzodiazepines and other sedatives that increase total sleep time but alter sleep architecture unfavorably by suppressing REM and deep sleep stages. Furthermore, the effect appears most pronounced when endogenous DSIP levels are low, suggesting a modulatory rather than directly sedating mechanism. Researchers who buy dsip can therefore study clean, physiologically relevant sleep promotion without the confounding factors of traditional sedatives.

HPA Axis and Stress Modulation

Research demonstrates that DSIP reduces corticotropin-releasing factor (CRF) activity and attenuates ACTH release, thereby dampening the stress-induced activation of the hypothalamic-pituitary-adrenal axis. Consequently, researchers use DSIP to study how sleep-related peptides influence stress hormone dynamics, HPA axis feedback loops, and the neuroendocrine basis of stress resilience.

Pain Perception and Opioid Interactions

Published studies indicate that DSIP modulates pain perception through mechanisms distinct from direct opioid receptor activation. Specifically, it appears to influence endogenous opioid peptide release and may potentiate natural pain-suppressing pathways without producing tolerance or dependence. Researchers studying non-opioid analgesia mechanisms incorporate DSIP into their peptide panels to dissect alternative pain modulation pathways.

Circadian Rhythm Research

DSIP levels in cerebrospinal fluid show diurnal variation, with peaks occurring during sleep periods. Consequently, researchers studying circadian biology use this peptide to investigate how sleep-associated signaling molecules influence the central and peripheral clocks that regulate 24-hour physiological rhythms.

DSIP Dosage Reference (When You Buy DSIP)

The following reference is compiled from published preclinical studies. It serves strictly as a laboratory research design context. We do not provide human dosing recommendations.

Research Model	Typical Dose	Route	Frequency	Notes
Rodent sleep architecture (EEG study)	30-100 nmol/kg (~25-85 µg/kg)	Intracerebroventricular or intraperitoneal	Single dose at sleep onset	Increased slow-wave sleep duration over 2-4 hours
Rodent stress/HPA axis model	50-100 µg/kg	Intraperitoneal	Single or repeated daily	Attenuated CRF and ACTH responses
Rabbit sleep model	30 nmol/kg (~25 µg/kg)	Intravenous or ICV	Single dose	Original model; robust delta-wave induction
Pain perception model	50-100 µg/kg	Intraperitoneal	Single dose	Modulation of pain thresholds without sedation

For researchers who buy dsip, the published dosage range of 30-100 nmol/kg provides the standard preclinical reference window. Importantly, effects on sleep architecture begin within 15-30 minutes and persist for 2-4 hours, consistent with the peptide’s short plasma half-life and presumed downstream signaling mechanisms.

How to Reconstitute DSIP

Step-by-Step Laboratory Protocol

1. Sanitize the vial stopper with 70% isopropyl alcohol.
2. Inject bacteriostatic water or sterile saline slowly against the vial wall. The small nonapeptide dissolves quickly, so avoid directing the stream at the lyophilized cake to minimize foaming.
3. Allow the powder to dissolve without agitation for 1 minute.
4. Gently swirl until the solution is fully clear. Do not shake vigorously.
5. Verify a clear, colorless solution. Discard if any turbidity remains.
6. Label with date and concentration.

Concentration Reference for 5mg Vial:

• 5mg vial + 1mL bacteriostatic water = 5 mg/mL
• 5mg vial + 2mL bacteriostatic water = 2.5 mg/mL
• 5mg vial + 5mL bacteriostatic water = 1 mg/mL

Storage Requirements:

• Lyophilized powder: 24 months at -20°C, protected from light and moisture.
• Reconstituted solution: 14 days at 2 to 8°C. Do not freeze.

Buy DSIP: Regulatory Context

Research Use Only

DSIP is not FDA approved for any human indication. It is an endogenous peptide used exclusively as a research tool to study sleep neurobiology, stress physiology, and neuroendocrine function. Researchers who buy dsip from Pure Peptide Factory receive a research-grade preparation sold strictly for in vitro and controlled laboratory animal studies. This product is not for human consumption, veterinary use, or diagnostic application. You must agree to research-use-only terms at checkout.

Product Specifications

Available Configuration

DSIP is available in 5mg lyophilized powder vials. This is the standard research configuration for this nonapeptide. Select your quantity from the product options above.

Quality Verification

• • Purity: 98% minimum (HPLC verified)
  • Identity: Mass spectrometry confirmed against the 848.82 g/mol molecular weight target with sequence verification
  • Endotoxin: Less than 0.1 EU/mL

• Sterility: Verified per USP 71
• Form: Lyophilized powder
• Storage: -20°C long-term, 2 to 8°C short-term after reconstitution
• CAS Number: 62568-57-4

Current Batch: #PPF-DSIP-0526
Purity: 98.8%
Download: HPLC Certificate | MS Report

Frequently Asked Questions

Where can I buy DSIP for research?

Pure Peptide Factory supplies research-grade DSIP domestically with same-day dispatch and cold-chain shipping. Orders placed before 2 PM EST ship same-day and most arrive within 1 to 3 business days with full HPLC and mass spectrometry documentation.

What is DSIP used for in research?

Researchers use DSIP to study sleep architecture (delta-wave promotion), HPA axis stress modulation, circadian rhythm regulation, non-opioid pain pathways, and neuroendocrine peptide signaling.

What are the primary dsip peptide benefits documented in research?

Published studies document increased slow-wave sleep without suppressing REM sleep, attenuation of stress-induced ACTH and cortisol release, modulation of pain perception through non-opioid mechanisms, and diurnal variation consistent with a role in circadian rhythm regulation.

What is the dsip dosage used in preclinical research?

In rodent sleep studies, the typical dose range is 30-100 nmol/kg (approximately 25-85 µg/kg) administered via intraperitoneal or intracerebroventricular injection. Refer to the dosage reference table above for model-specific details.

Is DSIP a sedative?

No. Unlike pharmacological sedatives, DSIP does not suppress neuronal activity globally. It appears to modulate endogenous sleep-regulatory circuits, promoting the natural transition into slow-wave sleep while preserving normal sleep architecture.

How should I store DSIP?

Store lyophilized powder at -20°C for up to 24 months. After reconstitution, keep the solution at 2 to 8°C and use within 14 days. Do not freeze reconstituted solution.

Is DSIP FDA approved?

No. DSIP is an endogenous peptide available strictly as a research compound. It has not received FDA approval for any human indication.

Can DSIP be used with other sleep-related research peptides?

Yes. Many researchers compare DSIP against Epitalon (pineal gland peptide) or Pinealon (CNS peptide) to dissect different aspects of sleep and circadian regulation. All compounds are available from our catalog for comparative research.

Buy DSIP for Your Research

Secure Checkout

• Credit card, cryptocurrency, or wire transfer
• Same-day dispatch for orders placed before 2 PM EST
• Cold-chain packaging with phase-change cooling
• Discreet labeling with full tracking

Institutional Accounts

Net-30 terms and purchase order acceptance available for universities and research institutions. Contact us for bulk pricing on 50 vials or more, including matched orders alongside our other neuroendocrine and sleep-related research peptides.

Add to cart and secure the most extensively characterized sleep-regulating nonapeptide for your neurobiology, stress, or circadian rhythm research program.